Programming and inheritance of parental DNA methylomes in vertebrates.
نویسندگان
چکیده
5-Methylcytosine (5mC) is a major epigenetic modification in animals. The programming and inheritance of parental DNA methylomes ensures the compatibility for totipotency and embryonic development. In vertebrates, the DNA methylomes of sperm and oocyte are significantly different. During early embryogenesis, the paternal and maternal methylomes will reset to the same state. Herein, we focus on recent advances in how offspring obtain the DNA methylation information from parents in vertebrates.
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عنوان ژورنال:
- Physiology
دوره 30 1 شماره
صفحات -
تاریخ انتشار 2015